Spider-Man (Peter Parker) is uniquely strong in combination with other web-tile creators like Spider-Gwen (Gwen Stacy) or Miles Morales (Spider-Man), as well as taking great advantage of Strike tile creators because of his multiple hit power in Arachnid Agility.

Web Shot is a tremendous potential source of damage when Spider-Man (Peter Parker) is combined with other 5* characters to take advantage of the tier's enhanced crit damage and cascade potential.

Optimal power layouts depend on whether he will operate with Black Bolt (Inhuman King) to take advantage of the possibility of The Silent King to generate a 5/5/5 effective power set when firing off the recommended attack sequence of Stick Around followed by one or more Arachnid Agility, with Web Shot saved for last to retain the maximum number of hits in the Arachnid Agility sequence.